PROPHYLACTIC LIPID LOWERING EFFECTS OF AQUEOUS EXTRACT OF EMILIA PREATEMISSA ON CARBON TETRACHLORIDE (CCL4)-INDUCED HYPERLIPIDEMIC ALBINO RATS

Objective: Hyperlipidemia has been described as one of the greatest risk factors contributing to prevalence and severity cardiovascular diseases which identified a primary cause death. This study evaluates lipid-lowering effects aqueous extract Emilia praetermissa (EP) leaves.
 Methods: The investigation was carried out on rats induced with Carbon tetrachloride (CCl4 1 ml/kg body weight), pretreated extracts then compared standard hypolipidemic drug, Simvastatin. lipid profile were assessed by measuring levels total cholesterol, triglyceride, low-density lipoprotein (LDL) high-density (HDL) cholesterol. effect HMGCoA Reductase Lecithine Cholesterol Acyltransferase (LCAT), are important enzymes in metabolism also evaluated plasma, liver heart albino rats.
 Results: Administration 50, 100 200 mg/kg doses leaves led significant reduction (P<0.05) LDL triglyceride increase HDL cholesterol tissues manner close that Normal Standard control group. activity LCAT inhibition reductase.
 Conclusion: These results suggest could play cardioprotective role probably serve new potential natural product for management hyperlipidema. Further investigations warranted elucidate mechanism its action.